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L-DOPAis synthesized from the amino acid L-tyrosine in the mammalian body and brain, it is the precursor to the neurotransmitters dopamine, norepinephrine, and epinephrine collectively known as catecholamines. L-DOPA can be manufactured and in its pure form is sold as a psychoactive drug with the INN levodopa. Aside from its natural and essential biological role, L-DOPA is also used in the clinical treatment of Parkinson's disease and dopamine-responsive dystonia.It is a prescription drug in the US