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The herb mainly distributes throughout the south, southeastern and northwest of China, and can also be found in middle part of Japan as well. As reported previously, the alkaloids were considered as main bioactive constituents of M.cordata. The main alkaloids in this plant include sanguinarine,chelerythrine, protopine, allocryptopine, dihydrosanguinarine, dihydrochelerythrine, oxysanguinarine, berberine .
