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Description:
aloe-emodin (AE), a hydroxyanthraquinone present in Aloe veraleaves, has a specific in vitro and in vivo antineuroectodermal tualoe-emodin (AE), a hydroxyanthraquinone present in Aloe veraleaves, has a specific in vitro and in vivo antineuroectodermaltumor activity. The growth of human neuroectodermal tumors isinhibited in mice with severe combined immunodeficiency without anyappreciable toxic effects on the animals. The compound does notinhibit the proliferation of normal fibroblasts nor that ofhemopoietic progenitor cells. The cytotoxicity mechanism consistsof the induction of apoptosis, whereas the selectivity againstneuroectodermal tumor cells is founded on a specificenergy-dependent pathway of drug incorporation. Taking into accountits unique cytotoxicity profile and mode of action, AE mightrepresent a conceptually new lead antitumor drug.
