Description:
Traditional Andmodernuses:Huzhang ("tiger cane") or giant knotweed is an east Asian species(Polygonum cuspidatum).
Giant KnotweedExtract Resveratrol
Traditional Andmodernuses:
Huzhang ("tiger cane") or giant knotweed isan east Asian species (Polygonum cuspidatum), belonging to thePolygonaceae family. documented uses in traditional Chinesemedicine date to the first century BC, and contemporary medicaluses supported by clinical results include acute microbialinfections or viral hepatitis, chemo- or radiation-inducedleukocytopenia, atherosclerosis, andhyperlipidemia.
Pharmacology:
In animal experiments, huzhang has exhibitedantitussive, antihistaminic, hypotensive, vasodilating, cytotoxic,and antioxidant properties, among others. Huzhang is also aconcentrated source of resveratrol (3, 5, 4¡Â-trihydroxy stilbene),an antioxidant phenol produced in response to fungi. Resveratrolhas also shown antimutagenic activity in bioassays conducted onbacteria in vitro (umu and Ames tests). And, in a recentinvestigation conducted in vivo and in vitro, resveratrol displayedchemopreventive effects at three critical stages ofcarcinogenesis.
Specifically, resveratrol was foundto
1) induce phase II drug metabolizing enzymes(antiinitiation);
2)mediate anti-inflammatory effects andinhibit cyclooxygenase and hydro-peroxidase(antipromotion);
3) induce human promyelocytic leukemia celldiferentiation (antiprogression). Resveratrol was also found toinhibit the development of preneoplastic lesions in vitro andtumorigenesis in vivo. Very recently, it was reported that Huzhangextract is one of the best active-oxygen scavengers for theprevention of skin aging induced by UV-irradiation and freeradical. Experiments conducted in vivo indicate that resveratrol isa potent vasodilator and inhibitor of platelet aggregation. Recentwork in dogs and humans indicate that other concentrated sources ofresveratrol (i.e., red wine and grape juice) eliminate cyclicblood-flow reductions caused by platelet-mediatedthrombosis.
Active Compounds:
Huzhang is characterized by anthraquinonesand their glycosides, napthoquinone, 3, 5, 4¡Â-trihydroxy stilbene(i.e., resveratrol), piceid, fallacinol, citreorosein, questin,questinol, protocatechuic acid, ( ) catechin, 2, 5-dimethyl-7-hydroxychromone, 7-hydroxy-4-methoxy-5-methylcoumarin, flavonols,polysaccharides, and condensed tannins.
Regulatory Status:
Under U.S. law, huzhang extract is regulatedas a dietary supplement. As of this writing, no Europeangovernments had issued monographs or regulations for nutraceuticaluses of huzhang. NOTE: The statements in this publication have notbeen evaluated by the FDA.
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