Specifications:

• Quality assurance, low prices, ample supply, logistics stronger.

Description:

ToxicApis for Injection 0.5mg 
Composition: 
ToxicApis is a yellowwish clear liquid secreted by bees venomous andaccessorius, comprised of polypeptides, enzymes and biogenic amine,excipients are mannitol and phosphate buffer. 
Characteristics: 
Awhite or almost white lyophilized mass or power. 
Indications: 
It isindicated in the treatment of rheumatic arthritis, RheumatoidArthritis, Ankylosing Spondylitis and other rheumatic disease, italso can be used for the adjuvant therapy of peripheralneuralgia. 
Dosageand directions for use: 
Forsubcutaneous injection, or intramuscularinjection. 
Adult:Initialdosage of 0.05mg, increase progressively by 0.1-0.2mg every otherday if there is not adverse reaction until to 0.25-0.5mg, once aday or once every two days, total dosage of 10mg as a course oftreatment. 
Children:halfdosage of the adult. 

Injectionsite: 
1.Limbs alternatesubcutaneous injection. 
2.Trigger pointinjection, based on the lesions position, inject around the triggerpoint. 
3.Point injection,refer to location of point of Traditional Chinese Medicine, injectat some points. 

Side-Effects: 
Thecommon side effect is local inflamed, fever, itch, not need fortreatment, avoid of scratching,  
A fewpatients may suffer from urticaria, discontinue drug or takeChlorphenamine Maleate. 
Rarelypalpebral edema may occur, discontinue drug and take ChlorphenamineMaleate. 
4.Thewhole body childness and fever are easy to occur when the dosageexceeds 1.5mg, continue administration may relieve the symptoms,when necessary, antipyretic and analgesic medicine may beadministrated appropriately. 
5..Rarelyhemoglobinuria, stomachache, diarrhea, nausea and vomiting, shock,tinnitus, headache, dizzy may occur, when those symptoms appear,discontinue the drug and take necessary symptomatic treatment. Forshock patients, following treatments should be taken:lie on theback, oxygen uptake, subcutaneous injection of 0.3-0.5 ml ofadrenaline(1:100), or intramuscular injection of 1 ml of ofadrenaline, or intravenous injection of 500 ml of hydrocortisoneglucose injection(dissolve 200mg of hydrocortisone with 500ml of10%of glucose injection). 
Contraindications: 
It iscontraindications in patients who have shown hypersensitivity tothis medicine. 
Thepatients of renal failure or with the diseases of hemopoieticsystem. 
Pregnantwomen. 
Warnings andPrecautions: 
Keepaway from blood vessel and nerve trunk when injection isperformed. 
Thepoints of face, hands and feet should be avoided when the pointinjection is adopted. 
Adiameter of 1-10cm of Red and swollen may occur at the injectionlocation, which will continue for 1-3 days, when the diameter ofinflamed part is more than 10 cm, the medicine should bediscontinued. 
OtherPhysiotherapy may be combined used when treatment with thismedicine. 
Thetreatment may be continued for 1-2 courses, other therapy may beadopted if there is not significant effect after treatment of 2courses. 
Caution should betaken for the patients with allergic constitution. 
Pregnant women andwomen in lactation: 
Thereare not studies and reference for this group. 
Pediatric use: 
Thereare not studies and references for this group. 
GeriatricUse: 
Thereare not studies and references for this group. 
DrugInteractions: 
Thereare not studies and references. 
Overdosage:Thereare not studies and references. 

PharmacologicalAction: 
ToxicApis has action against inflammatory reaction caused by immunecomplexes to be used for treatment of arthritis. 
ToxicApis has the action of antipyretic and analgesic, which react onCOX, with no addiction. 
Invitro, the concentration of 1:1000 of Toxic Apis has the action ofhemolysis, while platelet will not be damaged. 
PharmacologicalAction: 
ToxicApis has the action against inflammatory reaction caused by immunecomplexes to be used treatment of arthritis. 
ToxicApis has the action of antipyretic, which reat on COX, with noaddiction. 
Invitro, the concentration of 1:10000 of Toxic Apis has the action ofhemolysis, while platelet will not be damaged. 

Pharmacokinetics: 
Thereare not studies and references. 
Storage: 
Itshoould be stored in an airtight container, in a dry and darkplace, at a temperature not exceed 20 DegreesCelsius. 
ShelfLife: 2 years.