MOQ:1
Quantity:150
Definition
Heparin, a sulphated glucosaminoglycan,is widely distributed in mammalian liver, lungs, heart, kidney, thethymus, spleen, intestinal mucosa, muscle and blood. So it can beextracted from porcineintestineor bovine lungor porcine lung. Heparin sodium produced by our company isextracted from porcine intestine.It has the characteristic property of delaying the clotting offreshly shed blood.
Usage
Heparin Sodium is indicated for venous thrombosis and itsextension, acute myocardial infarction disease, hemodialysis and soon.
Specification
Test | Acceptance criteria |
Origin | Porcine intestinalmucosa |
Appearance | White or almost white,hygroscopic powder |
Solubility | Freely soluble inwater |
Identification | A:delays the clotting of sheepplasma B:1H-NMR: complieswith EP 7.0 specification of heparin sodium about 1H-NMRrequirements C:Chromatographic identity: theretention time and the shape of the principal peak from the samplesolution are similar to that from the standard solution D:complies with the test forsodium |
Appearance of solution | Clear and not more intenselycolored than intensity 5 of reference solution |
pH | 5.5~8.0 |
Nitrogen | 1.5%~2.5% |
Sodium | 9.5%~12.5% |
Nucleotide impurities | 260nm: not greater than0.15 |
Protein | Not more than 0.5% |
Related substances | Dermatan sulfate: Not more than2.0% Total impurities: Not more than3.0% |
Galactosamine | Not more than 1.0% |
Heavy metals | Not more than 20 ppm |
Loss on drying | Not more than 8.0% |
Bacterial endotoxins | Less than 0.01 IU/heparinIU |
Potency | At least 180 IU/mg |
Heparin Sodium: GMP, COA, DMFavailable
