Brand:YaxinBio
MOQ:10
Recombinant LipaseA
Biocatalyst with excellentenantioselectivity
SOURCE:
E.Coli
MOL. WEIGHT:
65 kDa
FORM:
Lyophilized powder, immobilized powder.
DEscriptION
Lipases (EC 3.1.1.3) are ubiquitous enzymes that catalyze thehydrolysis of fats and oils, and that play an important role inpharmaceutical. Lipases from Serratia marcescens (SML) arewell-known for their excellent enantioselectivity in biocatalytichydrolysis of trans-3-(4-methoxyphenyl) glycidic acid methyl ester[(±)-MPGM] to produce (2R, 3S)-3-(4-methoxyphenyl) glycidic acidmethyl ester [(-)-MPGM], a key intermediate for the synthesis ofdiltiazem hydrochloride.
APPLICATION
1) Hydrolysis of trans-3-(4-methoxyphenyl) glycidic acid methylester [(±)-MPGM] to produce (2R,3S)-3-(4-methoxyphenyl) glycidicacid methyl ester [(-)-MPGM].
2) Hydrolysis of (±)-naproxen methyl ester to produce(-)-naproxen.
3) Hydrolysis of fatty acid esters.
4) Catalysis of ester substitution reaction.
5) Production of biodiesel.
APPLICATION NOTES
PH-stability | pH 5~10 | |
Thermal-stability | Stable below 40°C, unstable at higher than50°C. | |
Stability against organicsolvents | Higher activity | In 10%-50% DMSO, isopropyl ether, petroleumether |
In 10%-25% ethanol, acetone and isopropanol | ||
In 90% isopropyl ether, petroleum ether | ||
50% activity | In 50% acetone and isopropanol | |
Selectivity to different fatty-acidderivatives | Priority to long-chain (> 10) fatty acid derivatives. | |
Main products: Recombinant carboxypeptidase B - Recombinanttrypsin - Recombinant protein A - Recombinant Trypsin Solution -Hyaluronidase - Recombinant enterokinase - V8 protease
