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chitosan oligosaccharide (cos) is kind of oligosaccharide (degree of polymerization<20), also known as chitin oligose. chemical name: β-(1, 4)-2-azyl-2-deoxy-d-glucan. cos has nh2+, which is the "unique natural active product with positive charge" in natural world, and it has very special physiological and biochemical functions. cos has a very broad application prospects in lots of fields such as medicine, food, agriculture, light industry and so on. cos can reduce the quantity of intestinal harmful microbe and increase the quantity of intestinal beneficial microbe, also improve the intestinal environment and promote the growth of the small intestine villi, which is good for the absorption of nutrient substance.