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Some dietary fibers have been demonstrated to activate intrinsic immune cells in humans. Daiwa has long focused research efforts on traditional Japanese and Oriental foods as immunoenhancing substances. This research eventually LED us to concentrate on soluble dietary fibers, hemicellulose B. BioBran, discovered by Daiwa, is a polysaccaride complex that contains biologically modified rice bran Arabinoxylan derivative as a major ingredient. Biobran is produced by the action of carbohydrate degrading enzymes, obtained from shiitake mushrooms, acting on hemicellulose B. Many papers have been published in Japan, the UK, and Europe on BioBran's beneficial effects, such as its immunoenhacing action. Process patent in 9 countries.